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Becaplermin (brand name Regranex) is a cicatrizant, available as a topical gel. Regranex is a human platelet-derived growth factor indicated along with good wound care for the treatment of lower extremity diabetic neuropathic ulcers. It is also known as "platelet-derived growth factor BB".
REGRANEX® (becaplermin) Gel. DESCRIPTION. REGRANEX Gel contains becaplermin, a recombinant human platelet-derived growth factor for topical administration. Becaplermin is produced by recombinant DNA technology by insertion of the gene for the B chain of platelet-derived growth factor (PDGF) into the yeast, Saccharomyces cerevisiae.Becaplermin has a molecular weight of approximately 25 KD and ...
Becaplermin (Regranex) is a topical gel medication prescribed to patients with diabetes to treat diabetic ulcers on the lower limbs to promote healing of the ulcers. Side effects, drug interactions, pregnancy safety, and dosage information should be reviewed prior to taking this medication.
If you are allergic to becaplermin; any part of becaplermin; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had. If you have a tumor where the drug is being used. This is not a list of all drugs or health problems that interact with becaplermin.
Becaplermin comes as a gel to apply to the skin. It is usually applied once a day to the ulcer. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
Becaplermin is used to treat ulcers of the foot, ankle, or leg in patients with diabetes. This medicine is a human platelet-derived growth factor, a substance naturally produced by the body that helps in wound healing.
Find patient medical information for Becaplermin Topical on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
Becaplermin is a recombinant human platelet-derived growth factor that promotes cellular proliferation and angiogenesis; 1 15 malignancies distant from the site of application have occurred with the use of becaplermin gel. 1 7 An increased incidence of cancer (or cancer mortality with repeated use of the drug) has been reported in patients ...
Regranex is indicated, in association with other good wound care measures, to promote granulation and thereby the healing of full-thickness, neuropathic, chronic, diabetic ulcers less than or equal to 5 cm 2.
Becaplermin is a homodimeric protein of approximately 23.4 kDa composed of two B chains linked together by a disulphide bond, mainly released from the platelets’ α-granules, and also by fibroblasts, macrophages, endothelial cells and keratinocytes . The growth factor acts by binding and activating specific cell surface tyrosine kinase ...