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Melphalan (trade name Alkeran, in former USSR also known as Sarcolysin) is a chemotherapy drug belonging to the class of nitrogen mustard alkylating agents.
Melphalan (Alkeran) chemotherapy side effects, how it's given, how it works, precautions and self care tips for treatment of multiple cancers
Melphalan, also known as L-phenylalanine mustard, phenylalanine mustard, L-PAM, or L-sarcolysin, is a phenylalanine derivative of nitrogen mustard.
Melphalan is a phenylalanine derivative of nitrogen mustard with antineoplastic activity. Melphalan alkylates DNA at the N7 position of guanine and induces DNA inter-strand cross-linkages, resulting in the inhibition of DNA and RNA synthesis and cytotoxicity against both dividing and non-dividing tumor cells.
Melphalan is an anti-cancer drug that falls in the class of nitrogen mustard alkylating agents. A phenylalanine derivative of mechlorethamine, melphalan is also known as L-Phenalalynine Mustard or L-PAM, or by its trade name for human use, Alkeran.
Melphalan Hydrochloride for Injection should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents.
original article The new england journal of medicine 906 n engl j med 359;9 www.nejm.org august 28, 2008 Bortezomib plus Melphalan and Prednisone
Melphalan Tablets are indicated in the treatment of multiple myeloma and advanced ovarian adenocarcinoma. Melphalan either alone or in combination with other drugs has a significant therapeutic effect in a proportion of patients suffering from advanced breast carcinoma.
High-dose chemotherapy followed by autologous hematopoietic stem-cell transplantation has been reported to provide higher response rates and better overall survival than standard chemotherapy in immunoglobulin-light-chain (AL) amyloidosis, but these two strategies have not been compared in a
Suzhou Leader Chemical Co.,Ltd. engaged in chemical raw material medicine, pharmaceutical intermediates and fine chemicals research and development, production, import and export trade of professional firms are high-tech enterprises in Jiangsu Province, Jiangsu Province ...